SnapShot: Mammalian Sirtuins

SnapShot: Mammalian Sirtuins

The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan. The seven mammalian sirtuins, SIRT1-7, share a highly conserved NAD+-binding catalytic core domain although they exhibit distinct expression patterns, catalytic activities, a...

Mammalian Sirtuins and Energy Metabolism

Sirtuins are highly conserved NAD+-dependent protein deacetylases and/or ADP-ribosyltransferases that can extend the lifespan of several lower model organisms including yeast, worms and flies. The seven mammalian sirtuins, SIRT1 to SIRT7, have emerged as key metabolic sensors that directly link environmental signals to mammalian metabolic homeostasis and stress response. Recent studies have she...

SnapShot: Mammalian TRP Channels

Sirtuins as regulators of mammalian aging

the discovery that overexpression of yeast Sir2 deacetylase extends lifespan by as much as 30% over a decade ago [1], much effort has been invested in researching whether this effect is conserved in higher organisms as well. Indeed, in wormsand flies, two separate groups found that SIR2 extended lifespan as well, by 50% and 18%, respectively [1]. In parallel to the work in worms and flies, rese...

SnapShot: Mammalian Rab Proteins in Endocytic Trafficking